Assessing Residual Cone Function in Retinitis Pigmentosa Patients

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S-cone function in patients with retinitis pigmentosa.

PURPOSE To determine whether short-wavelength-sensitive (S-) cones are more severely damaged in patients with retinitis pigmentosa than long-wavelength-sensitive (L-) and middle-wavelength-sensitive (M-) cones. To determine whether there are differences in the amount of S-cone damage in patients with dominant versus nondominant inheritance patterns. To accomplish these goals with methods that p...

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Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa

The major cause of hereditary blindness in North America is retinitis pigmentosa (RP), which is a group of inherited diseases of the retina characterized by the onset of night blindness, the early loss of the peripheral visual field, and the late loss of central vision. In the late stage of the disease when retinal degeneration approaches the macula and cone degeneration ensues, most patients f...

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Foveal cone optical density in retinitis pigmentosa.

We have used a color matching technique to estimate the optical density of the foveal cone photopigments in a group of patients with retinitis pigmentosa. We find that foveal cone optical density is reduced in patients with retinitis pigmentosa. This reduction of density can occur early in the disease process and is found in patients with minimal visual field loss or 20/20 visual acuity. Foveal...

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Local cone and rod system function in patients with retinitis pigmentosa.

PURPOSE To compare local cone and rod system function in patients with retinitis pigmentosa (RP) using electrophysiological and psychophysical techniques. METHODS Cone-mediated multifocal electroretinograms (M-ERGs), cone system threshold visual fields, rod-mediated M-ERGs, and rod system threshold visual fields were measured in seven patients with RP. RESULTS All the patients had normal co...

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ژورنال

عنوان ژورنال: Translational Vision Science & Technology

سال: 2020

ISSN: 2164-2591

DOI: 10.1167/tvst.9.13.29